Charlie Sheen, as Charles "Charlie" Harper, a hedonistic, never married jingle-writer
Jon Cryer, as Alan Jerome Harper, Charlie's twice-divorced Chiropractor brother
Angus T. Jones, as Jacob David "Jake" Harper, Alan's son
Holland Taylor, as Evelyn Harper, Charlie and Alan's mother
Conchata Ferrell, as their housekeeper Berta (recurring previously)
Melanie Lynskey, as their neighbor Rose, a sometime stalker of Charlie (starring Season 1, recurring thereafter)
Marin Hinkle, as Judith, Alan's ex-wife
April Bowlby, as Kandi, Alan's young second ex-wife (starring Season 3 Episode 13, recurring both before and after)
Only Sheen, Cryer, and Jones have appeared (and been credited) in every episode. Guest stars so far have included Emmanuelle Vaugier as Mia, Ryan Stiles (who starred with both Sheen and Cryer in Hot Shots!) as Dr. Melnick, Jane Lynch as the therapist, Jeri Ryan as Sherry, Martin Sheen as Rose's father, Denise Richards as Lisa, Richard Lewis as Stan, Teri Hatcher as Liz, Judy Greer as Myra, Heather Locklear as Laura Lane. Also, Sean Penn, Elvis Costello, Harry Dean Stanton, and Steven Tyler all appeared as themselves, among other guests.
Jon Cryer, as Alan Jerome Harper, Charlie's twice-divorced Chiropractor brother
Angus T. Jones, as Jacob David "Jake" Harper, Alan's son
Holland Taylor, as Evelyn Harper, Charlie and Alan's mother
Conchata Ferrell, as their housekeeper Berta (recurring previously)
Melanie Lynskey, as their neighbor Rose, a sometime stalker of Charlie (starring Season 1, recurring thereafter)
Marin Hinkle, as Judith, Alan's ex-wife
April Bowlby, as Kandi, Alan's young second ex-wife (starring Season 3 Episode 13, recurring both before and after)
Only Sheen, Cryer, and Jones have appeared (and been credited) in every episode. Guest stars so far have included Emmanuelle Vaugier as Mia, Ryan Stiles (who starred with both Sheen and Cryer in Hot Shots!) as Dr. Melnick, Jane Lynch as the therapist, Jeri Ryan as Sherry, Martin Sheen as Rose's father, Denise Richards as Lisa, Richard Lewis as Stan, Teri Hatcher as Liz, Judy Greer as Myra, Heather Locklear as Laura Lane. Also, Sean Penn, Elvis Costello, Harry Dean Stanton, and Steven Tyler all appeared as themselves, among other guests.
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